Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addresse Grant Number: PAR-25-442.

Eligibility requirements

All of the following criteria must be met:

• Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Govern
• Grant Number: PAR-25-442

What the funding covers

• See official listing for award details

How to apply

1. 1Applications must be submitted through grants.gov
2. 2Grant Number: PAR-25-442
3. 3Posted: 2025-06-17

Application tips