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Call for proposals to support the Public Procurement of Innovative Solutions (PPI) within European health systems.

European Union

Call for proposals to support the Public Procurement of Innovative Solutions (PPI) within European health systems. With a total budget of €24.50 million and individual awards ranging from €3.00 to €8.00 million, the initiative aims to bridge the gap between clinical needs and market-ready innovations. Unlike traditional research grants, this funding specifically targets consortia of procurers—such as hospitals and health authorities—to deploy solutions that facilitate the integration and coordination of care, ultimately making healthcare more personalized, accessible, and inclusive. Proposals must center on the deployment of organizational or technological innovations, such as Artificial Intelligence (AI) for hospital-to-home care coordination or advanced diagnostic tools for personalized medicine. The call prioritizes several vulnerable and high-need groups, including: Vulnerable Patients: Children, the elderly, and frail individuals with complex social and health needs; Chronic & Complex Conditions: People living with multi-morbidities, cancer, rare diseases, or concurrent physical and mental health conditions: and Inclusive Design: Applicants must account for gender and intersectional factors, such as caregiving responsibilities and socioeconomic health disparities, to ensure equitable access.

Call for proposals to modernize the regulatory science governing health technologies within the EU.

European Union

Call for proposals to modernize the regulatory science governing health technologies within the EU. With a total budget of €19.60 million and awards ranging from €4.00 to €6.00 million, the initiative focuses on updating methodologies for clinical evaluation and regulatory assessment. The goal is to ensure that legal frameworks keep pace with rapid innovation in areas such as artificial intelligence (AI), virtual human twins, and new approach methodologies (NAMs), while maintaining rigorous safety and performance standards. Proposals should target the improvement of existing methodologies or explore how novel information sources can provide satisfactory evidence for regulatory needs. Key focus areas include: Refining Evidence Requirements: Closing gaps in clinical evidence clarity and sufficiency for medical devices, in-vitro diagnostics, and substances of human origin (SoHO); Integrating Digital & Bio-medical Approaches: Examining how AI-enabled models, Real-World Data (RWD), and disease-relevant biophysical data can support clinical investigations and predict biological parameters; Optimizing Study Design: Using existing data to improve the planning of first-in-human studies, thereby enhancing participant safety and rationalizing resource use; and Special Populations & Unmet Needs: Exploring regulatory pathways, such as regulatory sandboxes, to accelerate the uptake of technologies for rare diseases and pediatric conditions.

Call for proposals to develop advanced Virtual Human Twins (VHTs).

European Union

Call for proposals to develop advanced Virtual Human Twins (VHTs). With a total budget of €35.00 million, this initiative aims to create dynamic, multiscale digital representations of individuals to better understand cancer onset and progression. These in-silico models are intended to revolutionize personalized medicine by allowing clinicians to simulate and select the most effective intervention options at various anatomical levels, from cellular molecular profiles to entire organ systems. The Commission expects to fund approximately four projects, with individual awards ranging between €8.00 and €9.00 million. Key activities include: Multiscale Modeling: Developing VHTs that integrate FAIR (Findable, Accessible, Interoperable, Reusable) data, including multi-omics, medical imaging, and real-world clinical data, while utilizing AR/VR for model visualization; Validation & Clinical Uptake: Updating and validating these models with longitudinal patient data to demonstrate their usability and capacity to deliver clinically meaningful observations in real-world treatment settings; Open Science & Infrastructure: Making all data and model assets available through the UNCAN.eu and the Advanced VHT Platform. Newly collected datasets must be recorded in the European Health Data Space (EHDS) catalogue; and Multidisciplinary Collaboration: Ensuring active cooperation between AI experts, healthcare professionals, and patients throughout the development process to ensure the models reflect human diversity, including age, sex, and gender.

Call for proposals to address the dual challenge of the healthcare sector’s environmental footprint and its vulnerability to climate change.

European Union

Call for proposals to address the dual challenge of the healthcare sector’s environmental footprint and its vulnerability to climate change. With a total budget of €45.00 million, this initiative seeks to develop and pilot inclusive, accessible interventions that reduce health vulnerabilities while simultaneously greening healthcare operations. As the health sector is responsible for nearly 5% of global greenhouse gas emissions, this call prioritizes the development of low-carbon medical technologies and evidence-based frameworks to quantify the health co-benefits of climate mitigation. The Commission intends to award several grants, with individual projects receiving between €7.00 and €8.00 million. Applicants are expected to focus on scalable and transferable solutions that can be applied across diverse regional and socio-economic contexts. Key activities include: Intervention Piloting: Developing tools to address climate-related health outcomes and reducing the vulnerability of healthcare infrastructures and supply chains; Decarbonization Technologies: Creating low-carbon medical devices and digital solutions to minimize the emission of pollutants into air, water, and soil; Methodology Development: Designing harmonized frameworks and metrics to assess the cost-benefit ratio of climate adaptation versus mitigation strategies in the health sector; and Community Preparedness: Exploring the role of primary care and lifestyle practices in increasing the resilience of individuals and local communities to environmental stressors.

Call for proposals to bolster the competitiveness of the EU biotechnology sector by advancing “closer-to-deployment” health innovations.

European Union

Call for proposals to bolster the competitiveness of the EU biotechnology sector by advancing closer-to-deployment health innovations. With a total budget of €29.50 million, this initiative specifically targets the field of regenerative medicine, providing follow-on funding for promising research previously supported by EU R&I actions. The goal is to bridge the gap between early-stage research and market readiness, accelerating the delivery of life-changing therapies to patients. The call seeks to fund high-impact projects with substantial awards to ensure innovations reach clinical or industrial maturity. Award Range: Between €6.00 and €8.00 million per project. To be successful, proposals must demonstrate a clear pathway from previous EU-funded success to future healthcare impact.

Call for proposals to fund research and innovation actions (RIAs) focused on advancing healthcare through digitalization and data exchange January 28, 2026; Horizon Europe funding opportunities ; Health Grants , Innovation grants , Research grants This initiative provides up to €43.

European Union

This initiative provides up to €43.3 million to fund pre-competitive research and innovation focused on novel tools and technologies that improve the prevention, diagnosis, treatment, and management of diseases. The call specifically targets the digital transformation of healthcare by exploiting the full potential of data exchange and digitalisation. Proposals must address an unmet public health need, such as diseases with a high patient burden or significant economic impact. Key focus areas include: Demonstrating how research can be translated into innovative solutions that fit into Europe’s fragmented healthcare systems; Leveraging advanced analytics and artificial intelligence to improve diagnostic accuracy, shorten time-to-market, and provide personalized health interventions; Ensuring that health technologies account for demographic trends and the real-life challenges of patients with complex chronic diseases. Selected projects are expected to contribute to the EU’s Life Sciences Strategy by strengthening the competitiveness of the European health industry and fostering technological leadership.