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Call for proposals to support projects that to address the significant challenge of low-value care, which is estimated to account for up to one-fifth of global healthcare spending.

European Union

Call for proposals to support projects that to address the significant challenge of low-value care, which is estimated to account for up to one-fifth of global healthcare spending. With a total budget of €38 million and individual awards expected around €10 million, the initiative seeks to develop evidence-based methodologies to identify, measure, and reduce wasteful medical practices. By reallocating these resources, the program aims to maximize health outcomes, improve the resilience of care systems, and reduce the environmental footprint of healthcare delivery. Selected projects must adopt a patient-centered, multidisciplinary approach to achieve the following: Identification and Measurement: Develop a deep understanding of how to detect low-value care throughout the healthcare process, including testing specific indicators for overuse, misuse, and unwarranted variation; Innovative Strategies: Pilot and scale effective strategies for reducing low-value care across diverse European settings, ensuring these solutions are transferable across different healthcare systems; Systems Analysis: Examine healthcare payment and financing models to determine if they unintentionally incentivize low-value care and evaluate alternative models that align with high-value patient outcomes; and Technological Integration: Utilize data models, digital tools, and artificial intelligence to identify inefficiencies and facilitate collaboration between international health registries and databases.

Call for proposals to conduct a comprehensive review of cardiovascular research and innovative healthcare solutions at national, EU, and international levels.

European Union

Call for proposals to conduct a comprehensive review of cardiovascular research and innovative healthcare solutions at national, EU, and international levels. With a total funding allocation of €1.90 million, this initiative aims to identify critical gaps in the field and establish a Strategic Research and Innovation Agenda (SRIA) to improve risk prediction, early detection, and screening for cardiovascular diseases (CVDs) and associated comorbidities like obesity and diabetes. Cardiovascular diseases currently represent the leading cause of death in the EU, accounting for over 1.7 million deaths annually and consuming approximately 11% of healthcare budgets, totaling €282 billion. The proposal is designed to support the upcoming EU Cardiovascular Health plan by integrating digital tools, Virtual Human Twins (VHT), and AI-driven methods. Key activities include: Gap Analysis and Mapping: Conducting a global review of research and innovation, with specific emphasis on addressing sex- and gender-related gaps in diagnosis and treatment; Overcoming Barriers: Generating a detailed report on the obstacles to personalized prevention and providing evidence-based recommendations to bypass these challenges; Inclusive Research Design: Integrating variables such as age, genetic predisposition, lifestyle, and racial or ethnic origin into data analysis to ensure findings are generalizable across diverse populations; Stakeholder Collaboration: Organizing multi-sectoral events to align healthcare providers, researchers, and policymakers, while involving Social Sciences and Humanities (SSH) experts to enhance societal impact.

Call for proposals to support the Public Procurement of Innovative Solutions (PPI) within European health systems.

European Union

Call for proposals to support the Public Procurement of Innovative Solutions (PPI) within European health systems. With a total budget of €24.50 million and individual awards ranging from €3.00 to €8.00 million, the initiative aims to bridge the gap between clinical needs and market-ready innovations. Unlike traditional research grants, this funding specifically targets consortia of procurers—such as hospitals and health authorities—to deploy solutions that facilitate the integration and coordination of care, ultimately making healthcare more personalized, accessible, and inclusive. Proposals must center on the deployment of organizational or technological innovations, such as Artificial Intelligence (AI) for hospital-to-home care coordination or advanced diagnostic tools for personalized medicine. The call prioritizes several vulnerable and high-need groups, including: Vulnerable Patients: Children, the elderly, and frail individuals with complex social and health needs; Chronic & Complex Conditions: People living with multi-morbidities, cancer, rare diseases, or concurrent physical and mental health conditions: and Inclusive Design: Applicants must account for gender and intersectional factors, such as caregiving responsibilities and socioeconomic health disparities, to ensure equitable access.

Call for proposals to modernize the regulatory science governing health technologies within the EU.

European Union

Call for proposals to modernize the regulatory science governing health technologies within the EU. With a total budget of €19.60 million and awards ranging from €4.00 to €6.00 million, the initiative focuses on updating methodologies for clinical evaluation and regulatory assessment. The goal is to ensure that legal frameworks keep pace with rapid innovation in areas such as artificial intelligence (AI), virtual human twins, and new approach methodologies (NAMs), while maintaining rigorous safety and performance standards. Proposals should target the improvement of existing methodologies or explore how novel information sources can provide satisfactory evidence for regulatory needs. Key focus areas include: Refining Evidence Requirements: Closing gaps in clinical evidence clarity and sufficiency for medical devices, in-vitro diagnostics, and substances of human origin (SoHO); Integrating Digital & Bio-medical Approaches: Examining how AI-enabled models, Real-World Data (RWD), and disease-relevant biophysical data can support clinical investigations and predict biological parameters; Optimizing Study Design: Using existing data to improve the planning of first-in-human studies, thereby enhancing participant safety and rationalizing resource use; and Special Populations & Unmet Needs: Exploring regulatory pathways, such as regulatory sandboxes, to accelerate the uptake of technologies for rare diseases and pediatric conditions.

Call for proposals to develop advanced Virtual Human Twins (VHTs).

European Union

Call for proposals to develop advanced Virtual Human Twins (VHTs). With a total budget of €35.00 million, this initiative aims to create dynamic, multiscale digital representations of individuals to better understand cancer onset and progression. These in-silico models are intended to revolutionize personalized medicine by allowing clinicians to simulate and select the most effective intervention options at various anatomical levels, from cellular molecular profiles to entire organ systems. The Commission expects to fund approximately four projects, with individual awards ranging between €8.00 and €9.00 million. Key activities include: Multiscale Modeling: Developing VHTs that integrate FAIR (Findable, Accessible, Interoperable, Reusable) data, including multi-omics, medical imaging, and real-world clinical data, while utilizing AR/VR for model visualization; Validation & Clinical Uptake: Updating and validating these models with longitudinal patient data to demonstrate their usability and capacity to deliver clinically meaningful observations in real-world treatment settings; Open Science & Infrastructure: Making all data and model assets available through the UNCAN.eu and the Advanced VHT Platform. Newly collected datasets must be recorded in the European Health Data Space (EHDS) catalogue; and Multidisciplinary Collaboration: Ensuring active cooperation between AI experts, healthcare professionals, and patients throughout the development process to ensure the models reflect human diversity, including age, sex, and gender.

Call for proposals to address the dual challenge of the healthcare sector’s environmental footprint and its vulnerability to climate change.

European Union

Call for proposals to address the dual challenge of the healthcare sector’s environmental footprint and its vulnerability to climate change. With a total budget of €45.00 million, this initiative seeks to develop and pilot inclusive, accessible interventions that reduce health vulnerabilities while simultaneously greening healthcare operations. As the health sector is responsible for nearly 5% of global greenhouse gas emissions, this call prioritizes the development of low-carbon medical technologies and evidence-based frameworks to quantify the health co-benefits of climate mitigation. The Commission intends to award several grants, with individual projects receiving between €7.00 and €8.00 million. Applicants are expected to focus on scalable and transferable solutions that can be applied across diverse regional and socio-economic contexts. Key activities include: Intervention Piloting: Developing tools to address climate-related health outcomes and reducing the vulnerability of healthcare infrastructures and supply chains; Decarbonization Technologies: Creating low-carbon medical devices and digital solutions to minimize the emission of pollutants into air, water, and soil; Methodology Development: Designing harmonized frameworks and metrics to assess the cost-benefit ratio of climate adaptation versus mitigation strategies in the health sector; and Community Preparedness: Exploring the role of primary care and lifestyle practices in increasing the resilience of individuals and local communities to environmental stressors.